Ischemia/reperfusion
injury is a reaction occurring after successful treatment of an acute
myocardial infarction or in the setting of solid organ transplantation. After
successful reperfusion of a previously occluded vessel
or a transplanted organ, an additional loss of otherwise
vital cells may occur, the so-called lethal ischemia-reperfusion injury.
This lethal
reperfusion injury is based on rapid tissue oxygenation, leading to a release
of reactive oxygen species (ROS) and inducing oxidative stress, endothelial
cell activation and inflammation.
Experimentally
the reperfusion injury can be attenuated via ROS-scavenging, vessel stabilizing
and anti-inflammatory interventions. Cytoprotective genes, such as heme
oxygenase-1 (HO-1), offer a therapeutic approach to address this problem.
Therefore, this review will focus on the beneficial effects of HO-1 in
ischemia/reperfusion injury.
No comments:
Post a Comment